军需科技学院学术报告

报 告 题 目：Discovery and Commercialization of Health Functional Food Ingredients Improving Obesity and Related Metabolic Complications

时 间：2014年8月8日，上午8：30-10：30

地 点：食品楼三楼会议室

报 告 人：朴太善教授

报告人简介：

Taesun Park, 毕业于加州大学戴维斯分校，现任韩国延世大学食品营养学教授，科研副校长等。担任Biotechnology Journal (Wiley-VCH Verlag GmbH & Co., KGaA, Weinheim, Germany)、International Journal of Obesity (Nature Publishing Group)、Molecular Nutrition & Food Reserch (WILEY-VCH Verlag GmbH & Co.) 等多家杂志社编委，主要研究方向为药物、营养成分及植物提取物的疗效评价等。

朴太善教授简介

□ NAME（姓名）: Taesun Park

□ DATE OF BIRTH（出生日期）: July 4, 1960

□AFFILIATION（单位）：Yonsei University, Seoul, Korea

□ ADDRESS（通讯地址）: 101-1103, Park Palace, Naesoo-dong, Jongro-gu, Seoul, 110-901, South Korea

□E-MAIL（邮箱）：tspark@yonsei.ac.kr

□ EDUCATION（教育经历）：

- Ph.D. (Nutrition), Univ. of California, Davis, USA, 1990

- M.S. (Nutrition), Univ. of Massachusetts, Amherst, USA, 1987

- M.S. (Nutrition), Yonsei University, South Korea, 1985

- B.S. (Food Science and Nutrition, Yonsei University, South Korea, 1983

□ EMPLOYMENT（工作经历）：

- 1995~ present Professor, Department of Food and Nutrition, Yonsei University, Seoul, South Korea

- 1994~1995 Research Associate, Pediatric Infectious Disease, Stanford University School of Medicine, USA

- 1991~1994 Postdoc, Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, USA

- 1990~1991 Postdoc, Department of Pediatrics, Stanford University School of Medicine, USA

□ MAJOR ADMINISTRATIVE POSITIONS IN YONSEI UNIVERSITY

- Feb. 2012~Jan. 2014 Vice President for Research Affairs, Yonsei University

- Feb. 2012~Jan. 2014 President of University-Industry Foundation, Yonsei University

- Feb. 2012~Jan. 2014 CEO of Yonsei University Technology Holdings

- Sept. 04~Aug. 08 Vice President, Office of External Affairs & Development

□ MAJOR COMMITTEE ASSIGNMENTS

- 2010-2013 Chairman, Advertisement Review Board, Korea Communications Standards Commission

- 2004~2009 Advisory Board Member, Review Board for Health Functional Foods Approval, Korean Food and Drug Administration

- 2004~2006 Advisory Board Member, Review Board for Labeling and Advertisement of Health Functional Foods, Korean Food and Drug Administration

- 2000~2008 Advisory Board Member, Advertisement Review Board, Korea Communications Standards Commission

- 2001~2005 Advisory Board Member, Korea Publication Ethics Commission

□ EDITORIAL APPOINTMENTS

- 2009~ Present Editorial Board Member & Guest Editor: Biotechnology Journal (Wiley-VCH Verlag GmbH & Co., KGaA, Weinheim, Germany)

- 2011~ Present Editorial Board Member: International Journal of Obesity (Nature Publishing Group)

- 2011~ Present Editorial Board Member: Molecular Nutrition & Food Reserch (WILEY-VCH Verlag GmbH & Co.)

- 2010~ Present Editorial Board Member: Nutrition Research and Practice (The Korean Nutrition Society and the Korean Society of Community Nutrition)

□ HONORS & AWARDS

- 1990 Sigma Xi

- Nov. 11, 2002 The Outstanding Research Award: The Korean Nutrition Society

- Mar. 8, 2007 The Outstanding Lecture Award: Yonsei University

- Mar. 14, 2008 The Outstanding Lecture Award: Yonsei University

- Dec. 22, 2009 The Outstanding Research Award: Yonsei University

- Dec. 2, 2011 The Outstanding Research Achievement Award: Yonsei University

□ MAJOR RESEARCH INTERESTS

- Efficacy Evaluation of pharmaceutical or nutraceutical compounds or plant extracts

- Discovery of novel anti-obesity compounds of plant origin and optimization of lead compounds for drug or health functional food developments

- Understanding molecular and cellular basis of diet-induced obesity and related metabolic diseases, such as insulin resistance, hyperlipidemia, fatty liver and chronic inflammation in animal models

- Nutrigenomics technology, which includes transcriptomics, proteomics, metabolomics and systems biology, are applied for elucidation of underlying mechanisms for the etiology of diet-induced obesity and its complications.

- Search for novel molecular markers of obesity and metabolic diseases which could eventually be applied to humans

□ RECENT PUBLICATIONS (SINCE 2009)

1) Taesun Park, Keunsook Cho, Sung-Hee Park, Dong-Hee Lee and Ha Won Kim. Taurine normalizes blood levels and urinary losses of selenium, chromium, and manganese in rats chronically consuming alcohol. Adv Expt Med Biol 643: 407-414, 2009 (SCIE IF 0.646).

2) SoYoung Kim, Taesun Park, and Ha Won Kim. Inhibition of apoptosis by taurine in macrophages treated with sodium nitroprusside. Adv Expt Med Biol 643: 481-489, 2009 (SCIE IF 0.646).

3) Hasuk Song, Hyemin Kim, Taesun Park, and Dong-Hee Lee. Characterization of myogenic differentiation under endoplasmic reticulum stress and taurine treatment. Adv Expt Med Biol 643: 253-261, 2009 (SCIE IF 0.646).

4) Yasmin H Neggers, Eun-Kyung Kim, Ju-Mi Song, Eun-Jung Chung, Young-Sook Um, Taesun Park. Mental retardation is associated with plasma omega-3 fatty acid levels and the omega-3/omega-6 ratio in children. Asia Pac J Clin Nutr 18(1): 22-28, 2009 (SCIE IF 1.180).

5) Yun-Young Cho, Eun-Young Kwon, Hye-Jin Kim, Yong-Bok Park, Ki-Teak Lee, Taesun Park, Myung-Sook Choi. Low trans structured fat from flexseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice. Food and Chemical Toxicology 47: 1550-1555, 2009 (SCI IF 2.393).

6) So-Hyun Kim, Seung-Ok Yang, Hee-Su Kim, Yujin Kim, Taesun Park, Hyung-Kyoon Choi. 1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet. Anal & Bioanal Chem 395: 1117-1124, 2009 (SCI IF 3.439).

7) Keunsook Cho, Seung-Jin Kim, Sung-Hee Park, Sojin Kim and Taesun Park. Protective effect of Codonopsis lanceolata root water extract against alcoholic fatty liver in the rat. J Medicinal Food 12(6): 1293-1301, 2009 (SCI IF 1.390).

8) Youngju Song, Chunho Bae, Dongho Woo, Yunjung Kim, Taesun Park. Immunomodulatory activity of type-4 resistant starch in the mesenteric lymph nodes of rats. J Medicinal Food 13(1): 205-210, 2010 (SCI IF 1.390).

9) Yunjung Kim and Taesun Park. DNA microarrays to define and search for genes associated with obesity. Biotechnol J 5: 99-112, 2010 (SCIE IF 3.446).

10) Seung-Jin Kim, Youngshim Choi, Hye-Seung Jun, Bo-Min Kim, Hye-Kyung Na, Young-Jun Surh and Taesun Park. High-fat diet stimulates IL-1 type I receptor-mediated inflammatory signaling in the skeletal muscle of mice. Molecular Nutrition and Food Research 54: 1014-1020, 2010 (SCI IF 4.356).

11) Ahreum Kim and Taesun Park. Diet-induced obesity regulates the galanin-mediated signaling cascade in the adipose tissue of mice. Molecular Nutrition and Food Research 54: 1361-1370, 2010 (SCI IF 4.356).

12) Yunjung Kim, Youngshim Choi and Taesun Park. Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling. Biotechnology Journal 5: 950-960, 2010 (SCIE IF 3.446).

13) Ui-Hyun Park, Seung Kew Yoon, Taesun Park, Eun-Joo Kim, and Soo-Jong Um. Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor γ. Journal of Biological Chemistry 286: 1354-1363, 2011 (SCI IF 5.328).

14) Soyoung Park, Youngshim Choi, Soo-Jong Um, Seung Kew Yoon, Taesun Park. Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice. Journal of Hepatology 54:984-993, 2011 (SCI IF 9.858).

15) Soyoung Kim, Yoojeong Jin, Youngshim Choi, Taesun Park. Resveratrol exerts anti-obesity effects via mechnisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochemical Pharmaclogy 81: 1343-1351, 2011 (SCI IF 4.2).

16) Gyeong-Min Do, Hea Young Oh, Eun-Young Kwon, Yun-young Cho, Su-kyung Shin, Hae-Jin Park, Seon-Min Jeon, Eunjung Kim, Cheol-Goo Hur, Taesun Park, Mi-Kyung Sung, Robin A. McGregor and Myung-Sook Choi. Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice. Mol Nutr Food Res 55: S173-S185, 2011 (SCI IF 4.356).

17) Seung-Jin Kim, Youngshim Choi, Youn-Hee Choi, Taesun Park. Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. J Nutritional Biochemistry 23: 113-122, 2012 (SCI IF 4.352).

18) Soomin Cho, Soyoung Park, Youngshim Choi and Taesun Park. Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet. J Nutritional Biochemistry 23: 192-201, 2012 (SCI IF 4.352).

19) Ui-Hyun Park, Hong-Suk Jeong, Eun-Young Jo, Taesun Park, Seung Kew Yoon, Eun-Joo Kim, Ji-Cheon Jeong, and Soo-Jong Um, Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells. J Agricultural and Food Chemistry 60: 3853-3860, 2012 (SCI IF 2.562).

20) Soyoung Kim, Hyejeong Jwa, Yasuko Yanagawa, and Taesun Park. Extract from Dioscorea batatas ameliorates insulin resistance in mice fed a high-fat diet. J Medicinal Food 15(6): 527-534, 2012 (SCI IF 1.461).

21) Youngshim Choi, Yunjung Kim, Soyoung Park, Ke Won Lee and Taesun Park. Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice. J Nutr Biochem 23: 1732-1739, 2012 (SCI IF 4.2).

22) Hyejeong Jwa, Youngshim Choi, Ui-Hyun Park, Soo-Jong Um, Seung Kew Yoon, and Taesun Park. Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling transduction in the livers of mice fed a high-fat diet. Biochemical Pharmacology 84: 1501-1510, 2012 (SCI IF 4.25).

23) Wonhee Hur, Sung Woo Kim, Young Ki Lee, Jung Eun Choi, Sung Woo Hong, Myeong Jun Song, Si Hyun Bae, Taesun Park, Soo-Jong Um, Seung Kew Yoon, Oleuropein reduces free fatty acid-induced lipogenesis via lowered extacellular signal-regulated kinase activation in hepatocytes. Nutr Res 32: 778-786, 2012 (SCI IF 1.974).

24) Eun-Young Kwon, Su-Kyung Shin, Yun-Young Cho, Un Ju Jung, Eunjung Kim, Taesun Park, Jung Han Yoon Park, Jong Won Yun, Robin A McGregor, Yong Bok Park and Myung-Sook Choi. Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity. BMC Genomics 13:450, 2012 (SCIE IF 4.07).

25) Sung A Jung, Miseon Choi, Sohee Kim, Rina Yu, and Taesun Park. Cinchonine prevents high-fat diet induced obesity through down-regulation of adipogenesis and adipose inflammation. PPAR Research Volume 2012, Article ID: 541204, 2012 (SCIE IF 2.727).

26) Areum Cha, Youngshim Choi, Yoojeong Jin, Mi-Kyung Sung, Yun-Chang Koo, Kwang-Won Lee, Taesun Park. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. J Biomedicine and Biotechnology, Special Issue: Natural Products for Medicine Volume 2012, Article ID: 1413595, 2012 (SCIE IF 1.225).

27) Yeji Choi, Yasuko Yanagawa, Sungun Kim, Wan Kyunn Whang and Taesun Park. Artemisia iwayomogi extract attenuates high-fat diet-induced obesity by decreasing the expression of genes associated with adipogenesis in mice. Evidence-based Complementary and Alternative Medicine (eCAM) Volume 2013, Article ID: 915953 2013 (SCIE IF 1.722).

28) Youngshim Choi, Soo-Jong Um, and Taesun Park. Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation. Int J Obesity 37: 881-884, 2013 (SCI IF 5.221).

29) Youngshim Choi, Yasuko Yanagawa, Soyoung Kim, and Taesun Park. Involvement of SIRT1-AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet. J Nutr Biochem 24: 1393-1400, 2013 (SCI IF 4.552).

30) Youngshim Choi, Cheol-Goo Hur and Taesun Park. Induction of olfaction and cancer-related genes in mice fed a high-fat diet as assessed through the mode-of-action by network identification analysis. PLoS ONE 8(3): e56610, 2013(SCIE IF 3.73).

31) Seoyoon Choi, Youngshim Choi, Yeji Choi, Sohee Kim, Jeehee Jang and Taesun Park. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chemstry 141: 3627-3635, 2013.(SCI IF 3.334).

32) Yun-Chang Koo, Chung-Oui Hong, Mi-Hyun Nam, Ji Hoon Kim, Sung-Yong Yang, Nam-Hee Won, Taesun Park, and Kwang-Won Lee. Inhibitory effect of Yellow Myrobalan (Terminalia chebula) extract on fibrosis induced by carbon tetrachloride in rat liver. Food Sci Biotechnol 22: 871-889, 2013 (SCIE IF 0.695).

33) Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Hye-Sun. Choi, Byung-Sam Kim, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Jung Han Yoon Park, and Rina Yu. Blockade of 4-1BB and 4-1BBL interaction reducesobesity-induced skeletal muscle inflammation. Mediators of Inflammation Volume 2013, Article ID 865159, 2013 (SCI IF 3.882).

34) Eunkyung Kim, Youngshim Choi, Jihee Jang and Taesun Park. Carvacrol protects against hepatic stetosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling. Evidence-based Complementary and Alternative Medicine (eCAM) Volume 2013, Article ID 290104 (SCIE IF 1.722).

35) Xiuting Li, Youngshim Choi, Yasuko Yanakawa and Taesun Park. Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway. Int J Obesity 38: 140-147, 2014 (SCI IF 5.22).

36) Sohee Kim, Youngshim Choi, Seoyoon Choi, Yeji Choi, and Taesun Park. Dietary camphene attenuates hepatic steatosis and insulin resistance in mice. Obesity 22:408-417, 2014 (SCI IF 4.284).

37) Ying Shen, Su Jin Song, Narae Keum, and Taesun Park. Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis. eCAM Volume 2014, Article ID 971890, 2014 (SCIE IF 1.722).

38) Sung Woo Kim, Wonhee Hur, Tian zhu Li, Young Ki Lee, Jung Eun Choi, Sung Woo Hong, Kwang-Soo Lyoo, Chan Ran You, Eun Sun Jung, Chan Kun Jung, Taesun Park, Soo-Jong Um, and Seung Kew Yoon. Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. Experimental & Molecular Medicine 46: e92; doi:10.1038/emm.2014.10, 2914 (SCI IF 2.573).

39) Su Jin Song, Sena Choi, and Taesun Park. Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice. eCAM Volume 2014, Article ID 718379, 2014 (SCIE IF 1.722).

40) Hye-Ji Noh, Chu-Sook Kim, Ji-Hye Kang, Jun-Young Park, Suck-Young Choi Soon-Myoung Hong, Hoon Yoo, Taesun Park, and Rina Yu. Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling. J Medicinal Food 17(5): 550-557, 2014 (SCI IF 1.642).

41) Olivia Mina Choi, Yong Hee Cho, Sena Choi, Gyoonhee Han, Do Sik Min, Taesun Park, and Kang-Yell Choi. The small molecule indirubin-3-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. Int J Obesity [Epub] doi:10.1038/ijo.2013.209, 2013. 12. 10 (SCI IF 5.221).

42) Thai Hien Tu, Chu-Sook Kim, Ji-Hye Kang, Il Seong Nam-Goong, Chang Woo Nam, Eun Sook Kim, Young Il Kim, Jung Il Choi, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Myung Sook Choi, and Rina Yu. Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters. Int J Obesity [Epub] doi: 10.1038/ijo.2013.222, 2013. 12. (SCI IF 5.221).

□ BOOK CHAPTERS

1) Taesun Park, Seung-Jin Kim., Chapter 15. Insulin resistance and inflammatory signaling pathways modulated by high-fat diet. (pp. 385-416) In: “Dietary modulation of cell signaling”, Editors: Young-Joon Surh, Zigang Dong, Enrique Cadenas, and Lester Packer, Taylor and Francis LLC CRC Press, 477 pages, 18 Chapters, Sept. 2008.

2) Taesun Park and Yunjung Kim., Phytochemicals as potential agents for prevention and treatment of obesity and metabolic diseases. (pp. 150-185), In: "Anti-Obesity Drug Discovery and Development", 2011, Vol. 1., Editors: Atta-ur-Rahman, M. Iqbal Choudhary. Bentham Science Publishers, 283 pages, 15 Chapters, July 2011 (eISBN: 978-1-60805-163-2)

□ PATENT APPLICATIONS AND REGISTRATION

1) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Sung-Hee Park, and Sojin Kim). Composition for preventing and treating alcoholic liver disease and alcoholic hyperlipidemia comprising the extract of Codonopsis lanceolata., Korea Patent No.: 10-0631073, Registration Date: Sept. 26, 2006.

2) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Kun-Koo Park, and Sung-Hee Park). A method for screening a drug for treating and preventing hyperlipidemia and atherosclerosis using gene maker and screening kit using thereby., Korea Patent No.: 10-0735831, Registration date: June 28, 2007.

3) Kwang Dong Pharm Co., Ltd., Seoul, Korea and University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park and Ha Won Kim). Composition containing Pterocarpus santalinus extract for the prevention and treatment of hyperlipidemia and fatty liver.,Korea Patent No.: 10-0756550, Registration date: Sept. 3, 2007.

4) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Kun-Koo Park, and Sung-Hee Park). A method for screening a drug for treating and preventing alcoholic hepatic disease using gene maker and screening kit using thereby., Korea Patent No.: 10-0757256, Registration date: Sept. 4, 2007.

5) Kwang Dong Pharm Co., Ltd., Seoul, Korea, and University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Ha Won Kim), Novel juniperanol compound and its uses., Korea Patent No.: 10-0878756, Registration date: Jan. 8, 2009.

6) Kwang Dong Pharm Co., Ltd., Seoul, Korea, and University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Ha Won Kim), Fractions for preventing or treating obesity, hypercholesterolemia or diabetes., Korea Patent No.: 10-0911623, Registration date: Aug. 4, 2009.

7) Kwang Dong Pharm Co., Ltd., Seoul, Korea, and University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Ha Won Kim), Uses of Sesquiterpene Derivatives., Korea Patent No.: 10-0905419, Registration Date: June 24, 2009, Patent Appl. No.: 10-2008-0089971, Filing date: Sept. 11, 2008.

- U.S. Patent No.: US 8,481,592B2, Date of Patent: July 9, 2013, U.S. Patent Appl. No.: 13/058,264, PCT Filed: Oct. 20, 2008.

- Mexico Patent Appl. No.: 2011/001594, Filing date: Feb. 9, 2011.

- EU Patent Appl. No.: 08 876930.2, Filing date: Mar. 7, 2011.

- Japan Patent Appl. No.: 2011-526796, Filing date: Jan. 31, 2011.

- Brazil Patent Appl. No.: 0823082-0, Filing date: Mar. 10, 2011

- China Patent No.: 1269618, Registration Date: Sept. 11, 2013.

8) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing or treating of obesity, dyslipidemia, fatty liver or insulin resistance syndrome comprising cinchonine as active ingredients., Korea Patent No.: 10-0946641, Registration Date: Mar. 3, 2010, Patent Appl. No.: 10-2010-0004901, Filing date: Jan. 19, 2010.

- U.S. Patent Appl. No.: 13/578,717, Filing date: Aug. 13, 2012, Foreign Appl. Priority No.: 10-2010-0004901, Foreign Appl. Priority Date: Jan. 19, 2010.

9) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Wan-Kyun Hwang) Compositions comprising extract from seeds of Litchi semen for preventing or treating fatty liver or obesity., Korea Patent No.: 10-0969170, Registration Date: July 2, 2010, Patent Appl. No.: 10-2010-0004913, Filing date: Jan. 19, 2010.

- China Patent Appl. No.: 201080061825.4, Filing date: July 19, 2012, Foreign Appl. Priority No.: 10-2010-0004901, Foreign Appl. Priority Date: Jan. 19, 2010.

- Indonesia Patent Appl. No.: W.00.2012.02903, Filing date: July 19, 2012, Foreign Appl. Priority No.: 10-2010-0004901, Foreign Appl. Priority Date: Jan. 19, 2010.

10) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Wan-Kyun Hwang, Ha-Won Kim) Novel uses of scopolin and its derivative., Korea Patent No.: 10-0981350, Registration Date: Sept. 3, 2010, Patent Appl. No.: 10-2010-0015532, Filing date: Feb. 22, 2010.

- U.S. Patent Appl. No.: 13/580,481, Filing date: Aug. 22, 2012, Foreign Appl. Priority No.: 10-2010-0015532 Foreign Appl. Priority Date: Feb. 22, 2010.

11) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Novel uses of piperonal., Korea Patent No.: 10-0992995, Registration Date: Nov. 2, 2010, Patent Appl. No.: 10-2010-0041249, Filing date: May 3, 2010.

- U.S. Patent Appl. No.: 13/695,651, Filing date: 2012. 11. 1, Foreign Appl. Priority No.: 10-2010-0041249, Foreign Appl. Priority Date: May 3, 2010.

12) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing and treating obesity comprising camphor as an active ingredient., Korea Patent No.: 10-1032313, Registration Date: April 25, 2011, Patent Appl. No.: 10-2009-0028030, Filing date: April 1, 2009.

13) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing and treating obesity comprising camphene as an active ingredient., Korea Patent No.: 10-1050429, Registration Date: July 13, 2011, Patent Appl. No.: 10-2009-0022937, Filing date: Mar. 18, 2009.

- U.S. Patent No.: US 8,552,069 B2, Date of Patent: Oct. 8, 2013, U.S. Patent Appl. No.: 13/256,461, Filing date: 2011. 9. 14, Foreign Appl. Priority No.: 10-2009-0022937, Foreign Appl. Priority Date: Mar. 18, 2009.

14) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Olfactory receptors implicated in metabolic diseases and use thereof., Korea Patent No.: 10-1050436, Registration Date: July 13, 2011, Patent Appl. No.: 10-2010-0125349, Filing date: Dec. 9, 2010.

- China Patent Appl. No.: 201180059445.1, Filing date: June 9, 2013, Foreign Appl. Priority No.: 10-2010-0125349, Foreign Appl. Priority Date: Dec. 9, 2010.

- U.S. Patent Appl. No.: 13/992,128, Filing date: June 6, 2013, Foreign Appl. Priority No.: 10-2010-0125349 Foreign Appl. Priority Date: Dec. 9, 2010.

- Japan Patent Appl. No.: 2013-543086, Filing date: June 7, 2013, Foreign Appl. Priority No.: 10-2010-0125349, Foreign Appl. Priority Date: Dec. 9, 2010.

15) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Kyun-Hee Han) Composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes comprising indole-3-carbinol derivatives as active ingredients., Korea Patent No.: 10-1056359, Registration Date: Aug. 5, 2011, Patent Appl. No.: 10-2011-0010585, Filing date: Feb. 7, 2011.

- U.S. Patent Appl. No.: 13/983,711, Filing date: Aug. 5, 2013. Foreign Appl. Priority No.: 10-2011-0010585, Foreign Appl. Priority Date: Feb. 7, 2011.

16) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing and treating fatty liver, hyperlipidemia or diabetes comprising carvacrol or pharmaceutically acceptable salt thereof as an active ingredient., Korea Patent No.: 10-1071894, Registration Date: Oct. 4, 2011, Patent Appl. No.: 10-2009-0008025, Filing date: Feb. 2, 2009.

17) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing and treating obesity comprising piperine or pharmaceutically acceptable salt thereof as an active ingredient., Korea Patent No.: 10-1078376, Registration Date: Oct. 25, 2011., Patent Appl. No.: 10-2009-0008026, Filing date: Feb. 2, 2009.

18) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing or treating of obesity comprising secoiridoid derivatives as active ingredients., Korea Patent No.: 10-1081451, Registration Date: Nov. 2, 2011, Patent Appl. No.: 10-2008-0129314, Filing date: Dec. 18, 2008.

19) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Novel uses of adipic acid., Korea Patent No.: 10-1101808, Registration Date: Dec. 27, 2011, Patent Appl. No.: 10-2011-0052770, Filing date: June 1, 2011.

- U.S. Patent No.: US8,614,250B2, Date of Patent: 2013. 12. 24, Patent Appl. No.: 13/484,246, Filing date: May 30, 2012, Foreign Appl. Priority No.: 10-2011-0052770, Foreign Appl. Priority Date: June 1, 2011.

20) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), The screening method of drugs for treating obesity and diagnosing method obesity in early stage using PBMC gene marker, and the kits thereby., Korea Patent No.: 10-1101756, Registration Date: Dec. 27, 2011, Patent Appl. No.: 10-2009-0031400, Filing date: April 10, 2009.

21) University-Industry Foundation, Chung-Ang University and University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Hyung-Kyoon Choi) Composition for distinction of obese tendency and a informational method for obese tendency., Korea Patent No.: 10-1118555, Registration Date: Feb. 14, 2012, Patent Appl. No.: 10-2009-0109391, Filing date: Nov. 12, 2009.

22) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Novel uses of nonenal., Korea Patent No.: 10-1116124, Registration Date: Feb. 7, 2012, Patent Appl. No.: 10-2011-0052753, Filing date: June 1, 2011.

- U.S. Patent Appl. No.: 13/484,241, Filing date: May 30, 2012, Foreign Appl. Priority No.: 10-2011-0052753, Foreign Appl. Priority Date: June 1, 2011.

23) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Lak Shin Jeong) Novel piperine derivatives and uses thereof., Korea Patent No.: 10-1186500, Registration Date: Sept. 21, 2012, Patent Appl. No.: 10-2012-0009362. Filing date: Jan. 31, 2012.

- PCT Appl. No.: PCT/KR2012/011548, Filing date: 2012. 12. 27, Foreign Appl. Priority No.: 10-2012-0009362. Foreign Appl. Priority Date: Jan. 31, 2012.

24) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Composition for preventing or treating of obesity, hyperlipidemia fatty liver or diabetes comprising indole-3-carbinol derivatives as active ingredients., Korea Patent No.: 10-1221973, Registration Date: Jan. 8, 2012, Patent Appl. No.: 10-2008-0129313, Filing date: Dec. 18, 2008.

25) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventors: Taesun Park, Wan-Kyun Hwang) Pharmaceutical compositions comprising an extract from Smilax China Linne for preventing or treating obesity, hyperlipidemia or fatty liver., Korea Patent No.: 10-1225486, Registration Date: Jan. 17, 2013, Patent Appl. No.: 10-2012-0033316, Filing date: Mar. 30, 2012.

- PCT Appl. No.: PCT/KR2013/002668, Filing date: Mar. 30, 2013, Foreign Appl. Priority No.: 10-2012-0033316, Foreign Appl. Priority Date: Mar. 30, 2012.

26) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park), Methods for preventing or treating hair loss or promoting hair growth comprising secoiridoid glucoside derivatives., Korea Patent No.: 10-1269490, Registration date: May 24, 2013, Patent Appl. No.: 10-2012-0074407, Filing date: July 9, 2012.

- U.S. Patent Appl. No.: 14/356,162, Filing date: May 4, 2014, Foreign Appl. Priority No.: 10-2012-0074407, Foreign Appl. Priority Date: July 9, 2012.

□ LICENSING OUT OF TECHNOLOGY

1) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology for anti-obesity drug candicate, including patents listed below, to Kwang Dong Pharm Co., Ltd., Seoul, Korea on Mar. 5, 2010. This technology has obtained the IND approval from the KFDA July, 2013 and are currently under the Phase 1 clinical trial:

- Composition containing Pterocarpus santalinus extract for the prevention and treatment of hyperlipidemia and fatty liver., Korea Patent No.: 10-0756550, Registration Date: Sept. 3, 2007.

- Novel juniperanol compound and its uses., Korea Patent No.: 10-0878756, Registration Date: Jan. 8, 2009.

- Fractions for preventing or treating obesity, hypercholesterolemia or diabetes., Korea Patent No.: 10-0911623, Registration Date: Aug. 4, 2009.

- Uses of Sesquiterpene Derivatives., Korea Patent No.: 10-0905419, Registration Date: June 24, 2009, Patent Appl. No.: 10-2008-0089971, Filing date: Sept. 11, 2008.

2) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology for anti-obesity drug candicate obtained from the seeds of Litchi semen L to Hyundae Pharm Co., Ltd., Seoul, Korea on Mar. 29, 2012:

- Compositions comprising extract from seeds of Litchi semen for preventing or treating fatty liver or obesity., Korea Patent No.: 10-0969170, Registration Date: July 2, 2010, Patent Appl. No.: 10-2010-0004913, Filing date: Jan. 19, 2010.

3) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology, composition for preventing or treating of obesity comprising secoiridoid derivatives as active ingredients (Korea Patent No.: 10-1081451, Registration Date: Nov. 2, 2011, Patent Appl. No.: 10-2008-0129314, Filing date: Dec. 18, 2008), to Samjung Flavor Co., Ltd., Seoul, Korea on July 16, 2012.

4) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology for nutraceutical candidate improving diabetes, including patents listed below, to Cho-Jung Co., Ltd., Seoul, Korea on Oct. 15, 2013:

- Novel uses of adipic acid., Korea Patent No.: 10-1101808, Registration Date: Dec. 27, 2011, Patent Appl. No.: 10-2011-0052770, Filing date: June 1, 2011; U.S. Patent No.: US8,614,250B2, Date of Patent: 2013. 12. 24, Patent Appl. No.: 13/484,246, Filing date: May 30, 2012, Foreign Appl. Priority No.: 10-2011-0052770, Foreign Appl. Priority Date: June 1, 2011.

5) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology for anti-obesity drug candicate, including patents listed below, to Dong-A Pharm Co., Ltd., Seoul, Korea on Dec. 3, 2013:

- Novel uses of scopolin and its derivative., Korea Patent No.: 10-0981350, Registration Date: Sept. 3, 2010, Patent Appl. No.: 10-2010-0015532, Filing date: Feb. 22, 2010; U.S. Patent Appl. No.: 13/580,481, Filing date: Aug. 22, 2012, Foreign Appl. Priority No.: 10-2010-0015532 Foreign Appl. Priority Date: Feb. 22, 2010.

6) University-Industry Foundation, Yonsei University, Seoul, Korea (Inventor: Taesun Park) licensed out the technology for anti-obesity and anti-hyperlipidemia drug candicate obtained from Smilax China Linne to Vidaon Health Food Co., Ltd., Seoul, Korea on Jan. 23, 2014:

- Pharmaceutical compositions comprising an extract from Smilax China Linne for preventing or treating obesity, hyperlipidemia or fatty liver., Korea Patent No.: 10-1225486, Registration Date: Jan. 17, 2013, Patent Appl. No.: 10-2012-0033316, Filing date: Mar. 30, 2012; PCT Appl. No.: PCT/KR2013/002668, Filing date: Mar. 30, 2013, Foreign Appl. Priority No.: 10-2012-0033316, Foreign Appl. Priority Date: Mar. 30, 2012.